UNC2541
Product Specifications
UNSPSC Description
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].
Target Antigen
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/unc2541.html
Purity
99.71
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C(C(NCCCC[C@@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3
Molecular Weight
471.57
References & Citations
[1]McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125510/UNC2541-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125510/UNC2541-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1612782-86-1
Available Sizes
Curated Selection
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