PSI-697
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].
Product Specifications
CAS Number
[851546-61-7]
Product Name Alternative
P-Selectin Inhibitor
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
P-selectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PSI-697.html
Purity
99.79
Solubility
DMSO : ≥ 45.8 mg/mL
Smiles
O=C(C1=C(O)C(CC2=CC=C(Cl)C=C2)=NC3=C(CCCC4)C4=CC=C13)O
Molecular Formula
C21H18ClNO3
Molecular Weight
367.83
Precautions
H302, H315, H319
References & Citations
[1]Bedard PW et al. Characterization of the novel P-selectin inhibitor PSI-697 [2- (4-chlorobenzyl) -3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis. J Pharmacol Exp Ther.|[2]Myers DD Jr et al. Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation. Thromb Haemost. 2007 Mar;97 (3) :400-7.|[3]Myers DD Jr et al. Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis. J Vasc Surg. 2006 Sep;44 (3) :625-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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