Recombinant Human BMPR2 protein (His tag)
Product Specifications
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6.
Abbreviation
BMPR2
Synonyms
BMP type II receptor; BMP type-2 receptor; BMPR-2; BMPR-II; Bone morphogenetic protein receptor type II
UniProt
Q13873
Accession Number
Q13873
Expression System
E.coli
Tag
N-His
Sequence
Ser27-Thr150
Field of Research
Signal Transduction, Stem Cells, Cardiovascular
Endotoxin
< 10 EU/mg of the protein as determined by the LAL method.
Purity
> 85% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
26 kDa
Observed Molecular Weight
35 kDa
Species
Human
Available Sizes
Frequently Asked Questions
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