5T4 Recombinant Rabbit Monoclonal Antibody [SU34-05]
Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene. TPBG is an antagonist of Wnt/β-catenin signalling pathway. 5T4 is an antigen expressed in a number of carcinomas. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG). 5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development.
Product Specifications
Product Name Alternative
Abbreviation
5T4 oncotrophoblast glycoprotein, WAIF1, TPBG
Swiss Prot
Q13641 Human, Q9Z0L0 Mouse, Q5PQV5 Rat
Cellular Locus
Cell membrane.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide within Human 5T4 aa 381-420 / 420.
Isotype
IgG
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IP
Positive Control
MCF-7 cell lysates, SK-Br-3 cell lysates.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000 ;IP: Use at an assay dependent concentration.
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 46 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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