Fadrozole (hydrochloride)

Fadrozole hydrochloride (CGS 16949A) is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.

Product Specifications

CAS Number

[102676-31-3]

Product Name Alternative

CGS 16949A; (Rac) -FAD286 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301, H361

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Fadrozole_hydrochloride.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic; warming) |H2O : 100 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(C2CCCC3=CN=CN23)C=C1.Cl

Molecular Formula

C14H14ClN3

Molecular Weight

259.73

Precautions

H301, H361

References & Citations

[1]Browne LJ, et al. Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J Med Chem. 1991 Feb;34 (2) :725-36.|[2]Gunson DE, et al. Prevention of spontaneous tumours in female rats by fadrozole hydrochloride, an aromatase inhibitor. Br J Cancer. 1995 Jul;72 (1) :72-5.|[3]Morales-Montor J, et al. Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis. Int J Parasitol. 2002 Oct;32 (11) :1379-87.