CU-32
CU-32 is a potent cGAS inhibitor with an IC50 of 0.45 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells[1].
Product Specifications
CAS Number
[2400954-16-5]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cu-32.html
Purity
98.8
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC(N)=NC(NC2=CC=C(I)C=C2)=N1)OC
Molecular Formula
C11H10IN5O2
Molecular Weight
371.13
References & Citations
[1]Padilla-Salinas R, et al. Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors. J Org Chem. 2020 Feb 7;85 (3) :1579-1600.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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