WWOX (NM_016373) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Synonyms
D16S432E; DEE28; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1
Gene ID
51741
UniProt
Q9NZC7, Q96KM3, A0A411HBC7
Accession Number mRNA
NM_016373
Chromosomal Location
16q23.1-q23.2
Expression System
HEK293T
Tag
C-Myc/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Function
Druggable Genome
Molecular Weight
46.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
WWOX
Species
Human
Protein ID
NP_057457
Overview
Recombinant protein of human WW domain containing oxidoreductase (WWOX), transcript variant 1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/51741
Uniprot URL
https://www.uniprot.org/uniprot/Q9NZC7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_016373
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_057457
Curated Selection
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