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CAY10602

CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells[1].

Product Specifications

CAS Number

374922-43-7

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/CAY10602.html

Concentration

10mM

Purity

98.69

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

NC1=C(S(=O)(C2=CC=CC=C2)=O)C3=NC4=CC=CC=C4N=C3N1C5=CC=C(F)C=C5

Molecular Formula

C22H15FN4O2S

Molecular Weight

418.44

Precautions

H315, H319, H335

References & Citations

[1]Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11 (8) :959-67.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

SIRT1

Available Sizes

Frequently Asked Questions

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