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CD144 Antibody [BV13] (PE)

Product Specifications

Background

The BV13 monoclonal antibody specifically reacts with mouse CD144 (VE-Cadherin), a 120 kDA type II Cadherin. CD144 is a hemophilic adhesion molecule of the endothelial cell line essential to maintaining cell layer integrity. It is involved in cell growth inhibition, migration, and survival.

NCBI Gene ID

12562

Swiss Prot

P55284

Host

Rat

Reactivity

Mouse

Clonality

Monoclonal

Clone

BV13

Conjugation

PE

Type

Primary Antibodies

Field of Research

Cancer

Purification

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Concentration

Batch dependent

Buffer

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=76-864

Fragment

Rat IgG1, kappa

Specificity

The BV13 monoclonal antibody specifically reacts with mouse CD144 (VE-Cadherin), a 120 kDA type II Cadherin.

Symbol

Cdh5

NCBI Official Name

Cadherin 5

NCBI Organism

Mus musculus

Background Reference 01

Noelle, R. J., Roy, M., Shepherd, D. M., Stamenkovic, I., Ledbetter, J. A., Aruffo, A. (1992) . A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.Proceedings of the National Academy of Sciences,89 (14), 6550-6554.

Background Reference 02

Roy, M., Aruffo, A., Ledbetter, J., Linsley, P., Kehry, M., Noelle, R. (1995) . Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses.European journal of immunology,25 (2), 596-603.

Background Reference 03

Van den Eertwegh, A. J., Noelle, R. J., Roy, M. E. E. N. A. K. S. H. I., Shepherd, D. M., Aruffo, A., Ledbetter, J. A., ... Claassen, E. (1993) . In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate TB cell interactions.The Journal of experimental medicine,178 (5), 1555-1565.

Other Product Names

7B4, Vec, VECD, Cd144, VEcad, VE-Cad, AA408225, Cdh5

Tested Applications

Flow

Physical Properties

Liquid

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