Mafenide (Acetate)

Mafenide Acetate is a potent sulfonamide antimicrobial agent. Mafenide Acetate exhibits antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Mafenide Acetate also exhibits antifungal activity against filamentous fungi (e.g., Lichtheimia and Aspergillus flavus) . Mafenide Acetate can be used in the research of skin grafts on burn wounds, post-traumatic invasive fungal infections, and bacterially contaminated wounds[1][2][3][4].

Product Specifications

CAS Number

[13009-99-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Mafenide-Acetate.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

O=S(C1=CC=C(CN)C=C1)(N)=O.CC(O)=O

Molecular Formula

C9H14N2O4S

Molecular Weight

246.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Haynes, B.W., Jr., Mafenide acetate in burn treatment. N Engl J Med, 1971. 284 (23) : p. 1324.|[2]Ashkan Afshari, et al. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39 (5) :736-738.|[3]Barsoumian A, et al. In vitro toxicity and activity of Dakin's solution, mafenide acetate, and amphotericin B on filamentous fungi and human cells. J Orthop Trauma. 2013 Aug;27 (8) :428-36. |[4]Baver Acaban M, et al. The effects of topical mafenide acetate application on skin graft survival in bacterial contaminated wounds. Burns. 2024 Mar;50 (2) :433-443.