KEAP1 (2-624), His-Tag Recombinant

KEAP1 (Kelch like ECH associated protein 1) is involved in Nrf2 (Nuclear factor erythroid 2-related factor (Nrf2) regulation. Nrf2 is a transcription factor that coordinates antioxidant and anti-inflammatory responses by increasing the expression of antioxidant proteins through binding to theARE (antioxidant response element) region of their promoters. Under basal conditions, Nrf2 is retained in the cytosol by cytoskeletal Keap1, a substrate recognition subunit of an E3 ligase complex which targets Nrf2 for degradation. Exposure to oxidative stress causes the release of Nrf2 from Keap1. Nrf2 translocates to the nucleus, where it binds toAREsand induces the expression of antioxidant and phase II proteins protecting the cell from oxidative damage. Both Nrf2 and Keap1 are attractive therapeutic targets.