Anti-Nav1.8 Na+ Channel Antibody

Mouse Monoclonal Antibody specific to Nav1.8 Na+ Channel

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Peripheral nerve sodium channel 3, PN3, Sensory neuron sodium channel, Sodium channel protein type X subunit α, Voltage-gated sodium channel subunit α Nav1.8

Gene Name

Scn10a

NCBI Gene ID

UniProt

Q62968

Accession Number

NP_058943.1

Cellular Locus

Cell membrane

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

Fusion protein, aa 1724-1956 (cytoplasmic C-terminus) of rat Nav1.8 (accession no. Q62968).

Target Antigen

Sodium channel protein type 10 subunit α

Target

Nav1.8 Na+ Channel

Clonality

Monoclonal

Isotype

IgG2a

Type

Antibody

Applications

WB, IHC, ICC/IF, AM

Field of Research

Ion Channels

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium which is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {PubMed:12514212, PubMed:8538791, PubMed:8626372}.

Additionnal Information

Immunoblotting: use at 1-10ug/mL. A band of ~220kDa is detected.Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/mL Immunofluorescence: use at 1-10ug/mL These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: Rat dorsal root ganglia or lysate of COS cells transiently expressing Nav1.8.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C.

Specificity

This antibody recognizes human, mouse, and rat Nav1.8. It does not cross-react with other Nav channels.

Formulation

PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.

Buffer pH

pH 7.4

Target Background

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Nav1.8 is a voltage-gated sodium channel that plays a critical role in the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Since Nav1.8 is not present in cardiac muscle or neurons in the CNS, blockers of Nav1.8 will not directly affect those cells and can have less side effects than current pain medications.

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