Ac-VAD-AFC
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases[1][2].
Product Specifications
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-vad-afc.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=C(C=C1C(F)(F)F)C=CC(NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)C(C)C)=O)C)=O)CC(O)=O)=O)=C2
Molecular Formula
C24H27F3N4O8
Molecular Weight
556.49
References & Citations
[1]Choi WS, et al. Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: protective role of Bcl-2. J Neurochem. 2001;77 (6) :1531-1541.|[2]Posadas I, et al. Acetaminophen induces human neuroblastoma cell death through NFKB activation. PLoS One. 2012;7 (11) :e50160.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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