NO-prednisolone

NO-prednisolone is a nitric oxide (NO) -releasing derivative of Prednisolone. NO-prednisolone potently stimulates IL-10 production in vivo.

Product Specifications

CAS Number

[327610-87-7]

Product Name Alternative

NCX-1015

UNSPSC

12352005

Target

Interleukin Related

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NO-prednisolone.html

Purity

99.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@](C(COC(C3=CC=C(CO[N+]([O-])=O)C=C3)=O)=O)(O)CC[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O

Molecular Formula

C29H33NO9

Molecular Weight

539.57

References & Citations

[1]Fiorucci S, et al. NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99 (24) :15770-5.|[2]Paul-Clark M, et al. 21-NO-prednisolone is a novel nitric oxide-releasing derivative of prednisolone with enhanced anti-inflammatory properties. Br J Pharmacol. 2000 Dec;131 (7) :1345-54.