Dyrk1A-IN-4
Product Specifications
UNSPSC Description
Dyrk1A-IN-4 (compound 48) is a potent and orally active DYRK1A and DYRK2 inhibitor with IC50s of 2 nM and 6 nM, respectively. Dyrk1A-IN-4 has anticancer effects[1].
Target Antigen
DYRK
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dyrk1a-in-4.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(F)(CN1C2=C(N=C1C)C=CC(C3=CC(N)=NC(N)=C3)=N2)F
Molecular Weight
322.29
References & Citations
[1]Csaba Weber, et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021 May 27;64(10):6745-6764.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-147066/Dyrk1A-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-147066/Dyrk1A-IN-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2091883-59-7
Available Sizes
Curated Selection
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