Bonannione A
Product Specifications
UNSPSC Description
Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].
Target Antigen
Apoptosis; Autophagy; Phosphatase
Type
Natural Products
Related Pathways
Apoptosis;Autophagy;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bonannione-a.html
Solubility
10 mM in DMSO
Smiles
O=C1C[C@H](OC2=C1C(O)=C(C(O)=C2)C/C=C(CC/C=C(C)\C)\C)C3=CC=C(C=C3)O
Molecular Weight
408.49
References & Citations
[1]Lai-Bin Zhang, et al. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulate. Nat Prod Bioprospect. 2016 Feb;6(1):25-30.|[2]Hyun-Kyu An, et al. Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One. 2014 Dec 9;9(12):e114607.|[3]Zora Vochyánová, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124896/Bonannione-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124896/
Clinical Information
No Development Reported
CAS Number
97126-57-3
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