HLM006474

HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 μM in A375 cells.

Product Specifications

CAS Number

[353519-63-8]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Early 2 Factor (E2F)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hlm006474.html

Purity

99.57

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C1=NC(C)=CC=C1C=C2)=C2C(NC3=NC=CC=C3)C(C=C4C)=CC=C4OCC

Molecular Formula

C25H25N3O2

Molecular Weight

399.48

Precautions

H302, H413

References & Citations

[1]Ma Y, et al. A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 2008 Aug 1;68 (15) :6292-9.|[2]Kurtyka CA, et al. E2F inhibition synergizes with paclitaxel in lung cancer cell lines. PLoS One. 2014 May 15;9 (5) :e96357.