8-Azaadenine

8-Azaadenine is an inhibitor of Xanthine Oxidase with an IC50 of 0.54 μM and a Ki of 0.66 μM. 8-Azaadenine can be produced via the metabolism of 8-Azaadenosine (HY-115686) and incorporated into polynucleotide chains together with 8-Azaguanine (HY-B1468) to affect purine metabolism. 8-Azaadenine can be used in the study of cancer[1][2][3].

Product Specifications

CAS Number

[1123-54-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/8-azaadenine.html

Purity

99.85

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

NC1=C(N=NN2)C2=NC=N1

Molecular Formula

C4H4N6

Molecular Weight

136.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Sheu SY, et al. Inhibition of xanthine oxidase by synthetic cytokinin analogues. Anticancer Res. 1997 Mar-Apr;17 (2A) :1043-9.|[2]Holý A, et al Acyclic nucleotide analogs derived from 8-azapurines: synthesis and antiviral activity. J Med Chem. 1996 Sep 27;39 (20) :4073-88.|[3]Bennett LL Jr, et al. Metabolism and metabolic effects of 8-azainosine and 8-azaadenosine. Cancer Res. 1976 Nov;36 (11 Pt 1) :3917-23.