PAT1inh-B01

PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl-/HCO3- exchanger) -mediated anion exchange (IC50: 350 nM) . PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders[1].

Product Specifications

CAS Number

[1775330-54-5]

UNSPSC

12352005

Target

Chloride Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pat1inh-b01.html

Purity

98.32

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(CCN(C2)C(CN3N=C(C(F)(F)F)C(Br)=C3C)=O)N=C4C=C(C5=CC=CC=C5)NN14

Molecular Formula

C22H18BrF3N6O2

Molecular Weight

535.32

References & Citations

[1]Cil O, et al. SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine. JCI Insight. 2021 Jun 8;6 (11) :e147699.