Carotegrast methyl

Carotegrast methyl (AJM300) is an orally active and selective α4 integrin antagonist. HCA2969, an active metabolite of Carotegrast methyl, is a specific and dual α4β1/α4β7 integrin antagonist. Carotegrast methyl prevents the development of colitis in mice[1].

Product Specifications

CAS Number

[401905-67-7]

Product Name Alternative

AJM300

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/carotegrast-methyl.html

Concentration

10mM

Purity

99.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC(C1=C(C=CC=C1Cl)Cl)=O)CC2=CC=C(C=C2)N3C(N(C4=C(C3=O)C=C(C=C4)N(C)C)C)=O)OC

Molecular Formula

C28H26Cl2N4O5

Molecular Weight

569.44

References & Citations

[1]Toshihiko Sugiura, et al. Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis. 2013 Dec;7 (11) :e533-42.