PapRIV
PapRIV is an agonist of BV-2 microglial cells, capable of activating microglial cells through an NF-κB-dependent pathway. PapRIV induces the expression of pro-inflammatory cytokines such as IL-6 and TNFα and increases the production of reactive oxygen species (ROS) . PapRIV can cross the blood-brain barrier[1].
Product Specifications
UNSPSC
12352209
Target
NF-κB
Type
Peptides
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/papriv.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC=N3)C(O)=O)=O)=O)=O)=O)=O)[C@H](CO)N
Molecular Formula
C38H53N9O13
Molecular Weight
843.88
References & Citations
[1]Janssens Y, et al. PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci Rep. 2021 May 21;11 (1) :10723.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
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