Recombinant Bcr Monoclonal Antibody
Product Specifications
Background
Break point cluster region protein (Bcr) is encoded by the Bcr gene. The Bcr gene, mapping on chromosome22, was orginally identified by its presence in the chimeric Bcr-Abl oncogene. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine / threonine kinase activity and is a GTPase-activating protein for RAC1 and CDC42. A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia.
Abbreviation
Bcr
UniProt
P11274
Host
Rabbit
Reactivity
Human; Rat
Immunogen
Recombinant human Bcr fragment
Target
Renal carcinoma antigen NY-REN; BCR; ALL; BCR1; CML; D22S11; D22S662; PHL; Breakpoint cluster region; Renal carcinoma antigen NY-REN-26; bcr; BCR1; Breakpoint cluster region; CML; D22S11; D22S662; PHL; Renal carcinoma antigen NY-REN-26
Clonality
Monoclonal,Recombinant
Clone
A591
Conjugation
Unconjugated
Applications
WB; IHC
Field of Research
Signal Transduction; Cancer
Purification
Protein A purified
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000; IHC 1:50
Buffer
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Shipping Conditions
Ice bag
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
160 kDa
Observed Molecular Weight
160 kDa
Isotype
IgG, κ
Available Sizes
Curated Selection
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