ZD-4190

ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer.

Product Specifications

CAS Number

[413599-62-9]

UNSPSC

12352005

Target

EGFR; VEGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ZD-4190.html

Concentration

10mM

Purity

98.08

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

COC1=CC2=C(NC3=CC=C(Br)C=C3F)N=CN=C2C=C1OCCN4N=NC=C4

Molecular Formula

C19H16BrFN6O2

Molecular Weight

459.27

References & Citations

[1]Yang M, et al. PET imaging of early response to the tyrosine kinase inhibitor ZD4190. Eur J Nucl Med Mol Imaging. 2011 Jul;38 (7) :1237-47. doi: 10.1007/s00259-011-1742-z. Epub 2011 Mar 1.|[2]Gaballah K, et al. The antiangiogenic agent ZD4190 prevents tumour outgrowth in a model of minimal residual carcinoma in deep tissues. Br J Cancer. 2009 Aug 4;101 (3) :418-23. doi: 10.1038/sj.bjc.6605092. Epub 2009 Jul 21.|[3]Checkley D, et al. Dynamic contrast-enhanced MRI of vascular changes induced by the VEGF-signalling inhibitor ZD4190 in human tumour xenografts. Magn Reson Imaging. 2003 Jun;21 (5) :475-82.