L-SelenoMethionine

L-SelenoMethionine, an L-isomer of Selenomethionine, is a major natural food-form of selenium. L-SelenoMethionin is a cancer chemopreventive agent that can reduce cancer incidence by dietary supplementation and induce apoptosis of cancer cells. L-SelenoMethionine also can increase expression of glutathione peroxidase[1][2][3].

Product Specifications

CAS Number

[3211-76-5]

UNSPSC

12352211

Hazard Statement

H301+H331, H373, H410

Target

Apoptosis; Endogenous Metabolite

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/L-SelenoMethionine.html

Purity

99.82

Solubility

DMSO : 1 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CC[Se]C

Molecular Formula

C5H11NO2Se

Molecular Weight

196.11

Precautions

H301+H331, H373, H410

References & Citations

[1]Schrauzer GN, et, al. Selenomethionine: a review of its nutritional significance, metabolism and toxicity. J Nutr. 2000 Jul;130 (7) :1653-6.|[2]Menter DG, et, al. Selenium effects on prostate cell growth. Cancer Epidemiol Biomarkers Prev. 2000 Nov;9 (11) :1171-82.|[3]Jornot L, et, al. Differential regulation of glutathione peroxidase by selenomethionine and hyperoxia in endothelial cells. Biochem J. 1995 Mar 1;306 (Pt 2) (Pt 2) :581-7.|[4]Nuth M, et, al. Mitigating effects of L-selenomethionine on low-dose iron ion radiation-induced changes in gene expression associated with cellular stress. Oncol Lett. 2013 Jul;6 (1) :35-42.|[5]Guan J, et, al. Effects of dietary supplements on space radiation-induced oxidative stress in Sprague-Dawley rats. Radiat Res. 2004 Nov;162 (5) :572-9.