ODM-203

ODM-203 is an orally active and selective FGFR/VEGFR inhibitor with IC50 values of 6, 11, 16, 5, 9, 26 and 35 nM for FGFR3/1/2 and VEGFR3/2/1/4, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment[1].

Product Specifications

CAS Number

[1430723-35-5]

Product Name Alternative

Saponin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

FGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/odm-203.html

Purity

99.62

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

CN(N=C1)C=C1C2=CC=C3C(N=CN3C4=CC(C5=CC=C(F)C=C5F)=CC(NS(C6CC6)(=O)=O)=C4)=C2

Molecular Formula

C26H21F2N5O2S

Molecular Weight

505.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Holmström TH, et al. ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity. Mol Cancer Ther. 2019 Jan;18 (1) :28-38.