NSC 66811
NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].
Product Specifications
CAS Number
6964-62-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-66811.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4
Molecular Formula
C23H20N2O
Molecular Weight
340.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2) -p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49 (13) :3759-62.|[2]Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9901236 Inquire
Fish Soluble Cluster of Differentiation 146 (SCD146) ELISA Kit
Sign In for Pricing
View Details 
GTR15097331 1 Vial
Lentiviral human ARL2BP shRNA (UAS) - Lentiviral human ARL2BP shRNA (UAS, RFP) (25)
Sign In for Pricing
View Details IL-0106-HP-0500 500 g
1-Ethyl-2,3-dimethylimidazolium bis (trifluoromethylsulfonyl) imide
Sign In for Pricing
View Details