NEK7 degrader-2
NEK7degrader-2 (Compound 25) serves as a NEK7 degrader. It demonstrates a dose-dependent ability to degrade NEK7 in macrophages derived from human peripheral blood mononuclear cells, and reduces the release of the pro-inflammatory cytokine IL-1β, induced by NLRP3 inflammasome activation. NEK7degrader-2 is applicable for research into inflammatory diseases.
Product Specifications
CAS Number
3037413-54-7
Smiles
O=C1NC (=O) C (N2C (=O) C3=CC=C (C=C3C2C) C4NCCCC4) CC1
Molecular Formula
C19H23N3O3
Molecular Weight
341.41
Notes
For research use only.
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