Met-AMS (TEA)

Met-AMS TEA (compound 50), a sulfamate analogue of methionyl adenylate, is a potent Escherichia coli methionyl-tRNA synthetase (MetRS) inhibitor (IC50 of 7 nM) [1].

Product Specifications

CAS Number

[1122489-97-7]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/met-ams-tea.html

Purity

91.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(=O)(NC([C@H](CCSC)N)=O)=O.CCN(CC)CC

Molecular Formula

C21H38N8O7S2

Molecular Weight

578.71

References & Citations

[1]Jeewoo Lee, et al. N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2003 Mar 24;13 (6) :1087-92.