Antitubercular agent-56

Antitubercular agent-56, a derivative of Questiomycin A, is a potent antitubercular compound effective when taken orally. By inhibiting FabD (Kd = 9.39 μM; IC50 = 49.60 μM), it compromises the cell membrane integrity of Mycobacterium tuberculosis. Antitubercular agent-56 demonstrates significant intracellular antimycobacterial activity against Mycobacterium tuberculosis (MTB) and drug-resistant MTB both in vitro and in vivo, making it valuable for tuberculosis (TB) research.