DC-PGKI
DC-PGKI is an orally active ATP-competitive inhibitor of PGK1, with an IC50 of 0.16 μM and a Kd of 99.08 nM. It stabilizes PGK1 both in vitro and in vivo, inhibiting glycolytic activity and PGK1's kinase function. This inhibition induces the accumulation of NRF2 (nuclear factor erythroid 2-related factor 2, NFE2L2), which then translocates to the nucleus, binds to the proximal regions of IL-1β and IL-6 genes, and inhibits their LPS-induced expression. DC-PGKI is applicable for research in colitis.
Product Specifications
CAS Number
2829198-49-2
Smiles
O=C (OCC) C1=NC=2C=C (Cl) C (Cl) =CC2N=C1N3CCN (C (=O) NC4=CC=C (C=C4) N5CCNCC5) CC3
Molecular Formula
C26H29Cl2N7O3
Molecular Weight
558.46
Storage Conditions
-20°C
Notes
For research use only.
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