Cot-IN-4
Cot-IN-4 (compound 32) is a potent inhibitor of cancer Osaka thyroid (COT) kinase, with an IC50 value of 6 nM. It effectively inhibits the phosphorylation of ERK (IC50: 60 nM) and suppresses the release of TNFα (IC50: 60 nM) . Additionally, Cot-IN-4 reduces the production of the pro-inflammatory cytokine IL-1β in macrophages stimulated by uric acid (IC50: 0.2 μM) . This compound is applicable for research in inflammatory diseases.
Product Specifications
CAS Number
1984784-10-2
Smiles
N1=CC=C (C=C1) C=2N=CC=3N=CC=4N=CN (C=5C=CC6=NC (=CC=C6C5) NC (C) CN7CCOCC7) C4C3C2
Molecular Formula
C30H28N8O
Molecular Weight
516.61
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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