RYL-634

RYL-634 is a potent broad-spectrum antiviral agent. It exerts its antiviral effects by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH), thereby blocking the pyrimidine supply necessary for viral replication. RYL-634 demonstrates significant inhibitory action against various viruses, with EC50 values of 7 nM for DENV, 20 nM for ZIKV, 4 nM for EV71, 5 nM for HCV, and 13 nM for HIV. This compound can be used for research into diseases associated with multiple viral infections.