SGC stimulator 1

SGC stimulator 1 is a carbonyl sulfide (COS) /H2S donor hybrid soluble guanylate cyclase (sGC) stimulator with an EC50 of 496 nM. It demonstrates significant H2S release properties and reduces fibrosis in cardiac fibroblasts treated with TGF-β1 by increasing H2S levels. sGC stimulator 1 exerts antifibrotic effects by activating sGC and elevating H2S concentrations. This compound is applicable for heart failure (HF) research.