P2Y1 antagonist 4

P2Y1 antagonist 4 is a selective blocker of the P2Y1 receptor with excellent penetration across the blood-brain barrier. It inhibits ADP-induced increases in cytosolic Ca2+ mediated by the P2Y1 receptor in washed rabbit platelets (IC50 = 1.95 μM) and platelet aggregation (IC50 = 3.24 μM) . P2Y1 antagonist 4 significantly elevates nuclear Nrf2 protein levels in H2O2-treated HT22 cells. It reduces infarct size in a mouse acute myocardial infarction model and is applicable in research on ischemic stroke and myocardial infarction.