MSU-43557

MSU-43557 is an inhibitor and antibacterial agent targeting Mycobacterium abscessus MmpL3, featuring low eukaryotic cytotoxicity, narrow antibacterial spectrum and low drug resistance incidence. It inhibits MmpL3, reduces the content of trehalose dimycolate, interferes with biofilm formation and reduces bacterial activity, and also exerts bactericidal effects on intracellular Mycobacterium abscessus. Combined with antibiotics, it produces additive or synergistic effects, suitable for research on multidrug-resistant strains and related infections of Mycobacterium abscessus.