Photosensitizer-7

Photosensitizer-7 is a photosensitizer (PS) that targets the endoplasmic reticulum (ER) with absorption and emission wavelengths at λab= 610 nm and λem= 622 nm, respectively. Under illumination, it shows an IC50 of 4.006 μM in HeLa cells and 3.28 μM in MCF-7 cells. Photosensitizer-7 is taken up by cells in a dose-dependent manner and primarily colocalizes with the ER. Light exposure induces dose-dependent intracellular ROS generation, reduces mitochondrial membrane potential, and increases apoptosis. Furthermore, Photosensitizer-7 significantly inhibits tumor growth in MCF-7 tumor-bearing mice, making it a valuable candidate for photodynamic anti-cancer research applications.