Faridoxorubicin
Faridoxorubicin (AVA-6000) is a prodrug that targets fibroblast activation protein alpha (FAPα) . It releases active doxorubicin through FAPα-mediated cleavage, enhancing drug exposure within tumors while reducing cardiac toxicity. Faridoxorubicin holds potential for research in solid tumors, such as liver metastases from colorectal cancer.
Product Specifications
CAS Number
1841402-73-0
Smiles
OC=1C2=C ([C@@H] (O[C@H]3C[C@H] (NC (=O) [C@H]4N (C ([C@H] (NC (=O) C=5C=CN=CC5) C) =O) CCC4) [C@H] (O) [C@H] (C) O3) C[C@@] (C (CO) =O) (O) C2) C (O) =C6C1C (=O) C=7C (C6=O) =C (OC) C=CC7
Molecular Formula
C41H44N4O14
Molecular Weight
816.81
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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