ASX-173
ASX-173 is an orally active asparagine synthetase (ASNS) inhibitor with an IC50 of 0.113 μM and a Ki of 0.4 nM. It enhances the anticancer activity of L-Asparaginase (ASNase) . When combined with ASNase, ASX-173 disrupts nucleotide synthesis and induces cell cycle arrest, apoptosis (apoptosis), and autophagy (autophagy) in leukemia cells. This combination also slows the growth of OCI-AML2 xenograft tumors. ASX-173 is applicable in research on acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers.
Product Specifications
CAS Number
2748800-08-8
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction
Smiles
C (NC (C1=CC=CC=C1) C2=CC=CC=C2) (=O) [C@@H]3N (C ([C@H] (CC) N) =O) C[C@H] ([C@@H]3O) C4=CC=C (F) C=C4
Molecular Formula
C28H30FN3O3
Molecular Weight
475.56
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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