BrBzGCp2

BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC50 of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity[1][2].

Product Specifications

CAS Number

[166038-00-2]

Product Name Alternative

S-p-Bromobenzylglutathione cyclopentyl diester

UNSPSC

12352005

Target

Glyoxalase (GLO)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brbzgcp2.html

Purity

99.00

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCC(OC1CCCC1)=O)[C@@H](NC(CC[C@H](N)C(OC2CCCC2)=O)=O)CSCC(C=C3)=CC=C3Br

Molecular Formula

C27H38BrN3O6S

Molecular Weight

612.58

References & Citations

[1]P J Thornalley, et al. Antitumor activity of S- (p-bromobenzyl) glutathione diesters in vitro: a structure-activity study. J Med Chem. 1996 Aug 16;39 (17) :3409-11.|[2]Margaret G Distler, et al. Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal. J Clin Invest. 2012 Jun;122 (6) :2306-15.|[3]Katherine M. J. McMurray, et al. GLO1 inhibitors for neuropsychiatric and anti-epileptic drug development. Biochem Soc Trans. 2014 Apr;42 (2) :461-7.|[4]Margaret G Distler, et al. Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility. Epilepsia. 2013 Apr;54 (4) :649-57.|[5]Tao Xu, et al. GW29-e0826 ARC Regulates Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury through Preventing the Opening of mPTP. J Am Coll Cardiol. 2018 Oct, 72 (16_Supplement) C27.