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BTZO-1

BTZO-1, a chemical probe, binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE) -mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].

Product Specifications

CAS Number

99420-15-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/btzo-1.html

Purity

99.32

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C13

Molecular Formula

C13H8N2OS

Molecular Weight

240.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Kimura H, et al. BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression.Chem Biol. 2010 Dec 22;17 (12) :1282-94.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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