NLRP3 modulator 8
NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM) . In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1β triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.
Product Specifications
CAS Number
3069891-88-6
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
FC1=CN=C (C (C) (C) C (NCC2=CC (Cl) =C (C3C (NC (CC3) =O) =O) C (Cl) =C2) =O) N=C1
Molecular Formula
C20H19Cl2FN4O3
Molecular Weight
453.3
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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