Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD41/CD61 (PAC-1 epitope) Alexa Fluor® 647

CD41 (platelet glycoprotein IIb, integrin alpha IIb) is composed of two subunits (120 kDa transmembrane alpha chain and 23 kDa extracellular beta chain) and interacts with CD61 (platelet glycoprotein IIIa, integrin beta 3) in the presence of calcium to form a functional adhesive protein receptor. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin, and it is involved in platelet aggregation.

Product Specifications

Certification

RUO

Immunogen

Human platelets

Target Antigen

CD41/CD61 (PAC-1 epitope)

Clone

PAC-1

Applications

ICC, FC (QC tested)

Format

Alexa Fluor® 647

Buffer

Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

References & Citations

*Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem. 1985 Sep 15;260 (20) :11107-14. , URL: http://www.ncbi.nlm.nih.gov/pubmed/2411729, *Shattil SJ, Cunningham M, Hoxie JA: Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry. Blood. 1987 Jul;70 (1) :307-15. , URL: http://www.ncbi.nlm.nih.gov/pubmed/3297204 , *Trikha M, Timar J, Lundy SK, Szekeres K, Cai Y, Porter AT, Honn KV: The high affinity alphaIIb beta3 integrin is involved in invasion of human melanoma cells. Cancer Res. 1997 Jun 15;57 (12) :2522-8., URL: http://www.ncbi.nlm.nih.gov/pubmed/9192835 , *Bourne JH, Colicchia M, Di Y, Martin E, Slater A, Roumenina LT, Dimitrov JD, Watson SP, Rayes J: Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2. Haematologica. 2021 Feb 1;106 (2) :626-629., URL: https://pubmed.ncbi.nlm.nih.gov/32354867/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody PAC-1 recognizes an extracellular activation-induced conformational epitope PAC-1 on CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor which mediates platelet aggregation.

Applications Notes

6

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgM kappa

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

FAME-2OH Kit 22, C10-C22
MBS393483 350 mg

FAME-2OH Kit 22, C10-C22

Ask
View Details
NPY1R Protein Vector (Mouse) (pPM-C-HA)
32112024 500 ng

NPY1R Protein Vector (Mouse) (pPM-C-HA)

Ask
View Details
Mouse Neuropeptide S (NPS) Elisa Kit
EK731370 96 Well

Mouse Neuropeptide S (NPS) Elisa Kit

Ask
View Details
ALPL Antibody
CSB-PA034215-01 50 µL

ALPL Antibody

Ask
View Details
ALPL Antibody
CSB-PA034215-02 100 µL

ALPL Antibody

Ask
View Details
Cat Phosphorylated Signal Transducer and Activator of Transcription 1 (PSTAT1) ELISA Kit
MBS9900733 Inquire

Cat Phosphorylated Signal Transducer and Activator of Transcription 1 (PSTAT1) ELISA Kit

Ask
View Details