Nur77 agonist-1
Nur77 agonist-1 (Compound 8f) is an orally active Nur77 agonist. It induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, while decreasing GPX4 protein expression. Nur77 agonist-1 binds with affinity to the ligand binding domain of Nur77, with a KD of 13.80 μM. It demonstrates significant antiproliferative activity against various breast cancer cells (IC50: 2.15-3.26 μM) and exhibits low cytotoxicity towards normal cells. This compound is useful for breast cancer research.
Product Specifications
CAS Number
2899254-71-6
Field of Research
Cell Biology, Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Metabolism Research, Signal Transduction
Smiles
O=C (NC1=CC=C (C=C1) C (=O) NN=CC=2C=CC=C (Cl) C2) NC3=CC=C4N=CC=CC4=C3
Molecular Formula
C24H18ClN5O2
Molecular Weight
443.885
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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