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TREX1 Recombinant Rabbit Monoclonal Antibody [PSH08-84]

Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy), and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

3' 5' exonuclease TREX1 antibody 3' repair exonuclease 1 antibody AGS1 antibody AGS5 antibody CRV antibody Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody DKFZp434J0310 antibody DNase III antibody DRN3 antibody HERNS antibody Three prime repair exonuclease 1 antibody TREX1 antibody

Abbreviation

Three-prime repair exonuclease 1 3'-5' exonuclease TREX1 Trex1

Swiss Prot

Q91XB0 Mouse

Cellular Locus

Nucleus, Cytoplasm, cytosol, Endoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant protein within mouse TREX1 aa 1-280.

Isotype

IgG

Clone

PSH08-84

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IP

Positive Control

RAW264.7 cell lysate, CTLL-2 cell lysate, J774A.1 cell lysate, RAW264.7.

Concentration

1 mg/mL

Dilution

WB: 1:2,000-1:5,000 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 34 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

Recombinant Antibody

Yes

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