TREX1 Recombinant Rabbit Monoclonal Antibody [PSH08-84]
Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy), and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
Three-prime repair exonuclease 1 3'-5' exonuclease TREX1 Trex1
Swiss Prot
Q91XB0 Mouse
Cellular Locus
Nucleus, Cytoplasm, cytosol, Endoplasmic reticulum membrane.
Host
Rabbit
Species Reactivity
Mouse
Immunogen
Recombinant protein within mouse TREX1 aa 1-280.
Isotype
IgG
Clone
PSH08-84
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, FC, IP
Positive Control
RAW264.7 cell lysate, CTLL-2 cell lysate, J774A.1 cell lysate, RAW264.7.
Concentration
1 mg/mL
Dilution
WB: 1:2,000-1:5,000 ;FC: 1:1,000 ;IP: 1-2μg/sample
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 34 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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