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Imidapril (hydrochloride)

Imidapril hydrochloride (TA-6366) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. Imidapril hydrochloride suppresses the conversion of angiotensin I to angiotensin II and thereby reduces total peripheral resistance and systemic blood pressure. Imidapril hydrochloride can be used for hypertension, type 1 diabetic, nephropathy and chronic heart failure research[1][2].

Product Specifications

CAS Number

89396-94-1

Product Name Alternative

TA-6366

UNSPSC

12352005

Hazard Statement

H315-H319-H361

Target

Angiotensin-converting Enzyme (ACE) ; MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Imidapril-hydrochloride.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H](CN1C)N(C([C@@H](N[C@H](C(OCC)=O)CCC2=CC=CC=C2)C)=O)C1=O)O.[H]Cl

Molecular Formula

C20H28ClN3O6

Molecular Weight

441.91

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364-P405-P501

References & Citations

[1]Robinson DM, et al. Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. Drugs. 2007;67 (9) :1359-78.|[2]Yamamoto D, et al. Molecular mechanism of imidapril for cardiovascular protection via inhibition of MMP-9. J Mol Cell Cardiol. 2007 Dec;43 (6) :670-6.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MMP-9

Available Sizes

Frequently Asked Questions

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