EP4 receptor antagonist 7
EP4 receptor antagonist 7 is a potent and selective small molecule antagonist of the PGE2 EP4 receptor (IC50 = 1.1 nM) . It effectively suppresses PGE2-mediated signaling and gene expression in macrophages in vitro and demonstrates synergistic antitumor activity with anti-PD-1 therapy in mouse colon cancer models by enhancing CD8+ T cell infiltration.
Product Specifications
CAS Number
3035217-40-1
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
O=C (O) C1=CC=C (C=C1) CNC (=O) C2=C3C=CC=CC3=NN2CC4=CC=C (C=C4) C (F) (F) F
Molecular Formula
C24H18F3N3O3
Molecular Weight
453.413
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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