SMD-1087
SMD-1087 is a potent and selective SMARCA2 PROTAC degrader (DC50 = 8 nM, Dmax = 89%) with minimal activity against SMARCA4 (DC50 >1 μM) . Its structure comprises an (S, R, S) -AHPC-Me E3 ligase ligand, an SMI-1074-based warhead, and a defined linker. This tool compound is valuable for investigating SMARCA2-dependent biology and targeted protein degradation in cancer research models.
Product Specifications
CAS Number
3033586-04-5
Field of Research
Pharmacology & Drug Discovery
Smiles
O=C1N=C2C3 (C=4C (N2C=5C1=C (Cl) C=CC5) =CC (=CC4) C6CCN (C[C@H]7CC[C@H] (C (N[C@H] (C (=O) N8[C@H] (C (N[C@@H] (C) C9=CC=C (C=C9) C=%10SC=NC%10C) =O) C[C@@H] (O) C8) C (C) (C) C) =O) CC7) CC6) CCCCC3
Molecular Formula
C56H68ClN7O5S
Molecular Weight
986.701
Storage Conditions
-20°C
Notes
For research use only.
Available Sizes
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