WZ4003
WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5) /NUAK2, without significant inhibition on other 139 kinases.
Product Specifications
CAS Number
[1214265-58-3]
UNSPSC
12352005
Hazard Statement
H302
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WZ4003.html
Purity
98.03
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=CC(OC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)CC
Molecular Formula
C25H29ClN6O3
Molecular Weight
496.99
Precautions
H302
References & Citations
[1]Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457 (1) :215-25.|[2]Zhou W, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462 (7276) :1070-4
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NUAK1; NUAK2
Available Sizes
Curated Selection
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