WZ4003

WZ4003 is the first potent and highly specific NUAK kinase inhibitor with IC50 of 20 nM/100 nM for NUAK1 (ARK5) /NUAK2, without significant inhibition on other 139 kinases.

Product Specifications

CAS Number

[1214265-58-3]

UNSPSC

12352005

Hazard Statement

H302

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WZ4003.html

Purity

98.03

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(OC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)CC

Molecular Formula

C25H29ClN6O3

Molecular Weight

496.99

Precautions

H302

References & Citations

[1]Banerjee S, et al. Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases. Biochem J. 2014 Jan 1;457 (1) :215-25.|[2]Zhou W, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24;462 (7276) :1070-4