AS1708727
AS1708727 is an orally active Foxo1 inhibitor, with EC50 values of 0.33 μM and 0.59 μM for G6Pase and PEPCK, respectively[1].
Product Specifications
CAS Number
1253226-93-5
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/as1708727.html
Purity
99.44
Solubility
DMSO : 41.67 mg/mL (ultrasonic)
Smiles
O=C(CC1CCCC1)N(C)C2=CC=C(C(COC3=CC=CC4=C3C=CN=C4)=C2Cl)Cl
Molecular Formula
C24H24Cl2N2O2
Molecular Weight
443.37
References & Citations
[1]Hirotsugu Tanaka, et al. Effects of the Novel Foxo1 Inhibitor AS1708727 on Plasma Glucose and Triglyceride Levels in Diabetic Db/Db Mice. Eur J Pharmacol. 2010 Oct 25;645 (1-3) :185-91.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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