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Anti-Hu CD245 PE

CD245 is a 220-250 kDa transmembrane protein of unknown structure. It is expressed at lower level on resting blood lymphocytes, granulocytes, platelets, and thymocytes, and at high level on monocytes and on IL-2-dependent T cell lines. It is also expressed on Ewing sarcoma and osteosarcoma cell lines. CD245 seems to act as a costimulation molecule of T and NK cells.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human NK-type YT2C2 cells

Target Antigen

CD245

Clone

DY12

Applications

FC (QC tested)

Format

PE

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Kishimoto et al.: Leucocyte typing VI, Garland Publishing 1996, URL: , *Mason et al.: Leucocyte typing VII, Oxford University Press 2000, URL:

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody DY12 recognizes an extracellular epitope of CD245, a transmembrane protein expressed mainly by peripheral blood lymphocytes, NK cells, monocytes, granulocytes and platelets.

Applications Notes

6

Isotype

Mouse IgG1 kappa

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